| Week 1 | Arizona Cardinals vs. Buffalo Bills | Sunday, September 8th, 2024 at 1:00pm ET |
| Week 2 | Buffalo Bills vs. Miami Dolphins | Thursday, September 12th, 2024 at 8:15pm ET |
| Week 3 | Jacksonville Jaguars vs. Buffalo Bills | Monday, September 23rd, 2024 at 7:30pm ET |
| Week 4 | Buffalo Bills vs. Baltimore Ravens | Sunday, September 29th, 2024 at 8:20pm ET |
| Week 5 | Buffalo Bills vs. Houston Texans | Sunday, October 6th, 2024 at 1:00pm ET |
| Week 6 | Buffalo Bills vs. New York Jets | Monday, October 14th, 2024 at 8:15pm ET |
| Week 7 | Tennessee Titans vs. Buffalo Bills | Sunday, October 20th, 2024 at 1:00pm ET |
| Week 8 | Buffalo Bills vs. Seattle Seahawks | Sunday, October 27th, 2024 at 4:05pm ET |
| Week 9 | Miami Dolphins vs. Buffalo Bills | Sunday, November 3rd, 2024 at 1:00pm ET |
| Week 10 | Buffalo Bills vs. Indianapolis Colts | Sunday, November 10th, 2024 at 1:00pm ET |
| Week 11 | Kansas City Chiefs vs. Buffalo Bills | Sunday, November 17th, 2024 at 4:25pm ET |
| Week 12 | Bye Week | |
| Week 13 | San Francisco 49ers vs. Buffalo Bills | Sunday, December 1st, 2024 at 8:20pm ET |
| Week 14 | Buffalo Bills vs. Los Angeles Rams | Sunday, December 8th, 2024 at 4:25pm ET |
| Week 15 | Buffalo Bills vs. Detroit Lions | Sunday, December 15th, 2024 at 4:25pm ET |
| Week 16 | New England Patriots vs. Buffalo Bills | Sunday, December 22nd, 2024 at 1:00pm ET |
| Week 17 | New York Jets vs. Buffalo Bills | Sunday, December 29th, 2024 at 1:00pm ET |
| Week 18 | Buffalo Bills vs. New England Patriots | Sunday, January 5th, 2025 at 1:00pm ET |
